IndraLab

Statements

OTUB1 activates TGFB. 12 / 14
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"OTUB1 also contributes to the regulation of apoptosis and transforming growth factor-β (TGFβ) signalling by hindering ubiquitination of p53 (Sun et al., 2012) and phospho-suppressor of mothers against decapentaplegic 2 and 3 (SMAD2/3) (Herhaus et al., 2013), respectively."
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"OTUB1 has been found to modulate TGFbeta signalling by promoting the stabilization of only the phosphorylated form of SMAD2/3 [98]."
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"OTUB1 activates TGF-beta signaling via activating (phospho-) SMAD2/3."
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"The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury."
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"However, different from USP15, OTUB1 enhances TGF-beta signaling by inhibiting the ubiquitination and degradation of active SMAD2/3 (and not the inactive un phosphorylated form), because the association of OTUB1 to SMAD2/3 is phosphorylation dependent."
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"The inhibition of OTUB1 attenuated the TGF-β1-induced inflammation and remodeling."
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"These results suggest that Otub1 enhances TGFbeta induced transcriptional responses."
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"OTUB1 also inhibits DNA damage repair and promotes transforming growth factor-β signaling pathway independently of its DUB activity (12, 17)."
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"The expression of DUB OTU domain-containing Ub aldehyde-binding protein 1 (OTUB1) was significantly elevated in a TGF-β1-induced human bronchial epithelial cell model and in the bronchial mucosal tissues of asthma patients."
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"Our findings indicate that OTUB1 modulates TGFbeta induced transcriptional responses."
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"OTUB1 enhanced TGF-β signaling as a DUB of R-Smads [ 64 ]."
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"OTUB1, a member of ovarian tumor domain protease (OTU) family of DUBs, is confirmed to play an important role in the TGF-β-mediated gene transcription and cellular migration and enhance TGF-β signaling by inhibiting the ubiquitylation and degradation of phospho-SMAD2/3 [24]."
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