IndraLab

Statements

OTUB1 activates TGFB. 8 / 10
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"OTUB1 has been found to modulate TGFbeta signalling by promoting the stabilization of only the phosphorylated form of SMAD2/3 [98]."
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"OTUB1, a member of ovarian tumor domain protease (OTU) family of DUBs, is confirmed to play an important role in the TGF-β-mediated gene transcription and cellular migration and enhance TGF-β signaling by inhibiting the ubiquitylation and degradation of phospho-SMAD2/3 [24]."
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"These results suggest that Otub1 enhances TGFbeta induced transcriptional responses."
24071738
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"However, different from USP15, OTUB1 enhances TGF-beta signaling by inhibiting the ubiquitination and degradation of active SMAD2/3 (and not the inactive un phosphorylated form), because the association of OTUB1 to SMAD2/3 is phosphorylation dependent."
24756567
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"The inhibition of OTUB1 attenuated the TGF-β1-induced inflammation and remodeling."
36976509
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"Our findings indicate that OTUB1 modulates TGFbeta induced transcriptional responses."
24071738
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"The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury."
36976509
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"OTUB1 activates TGF-beta signaling via activating (phospho-) SMAD2/3."
24756567