IndraLab

Statements

USP5 activates MAF. 6 / 6
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"In the functional studies, USP5 was found to promoted the transcriptional activity of c-Maf."
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"In myeloma cells, USP5 stabilizes the c-Maf transcription factor, where inhibition of USP5 promotes c-Maf degradation and leads to apoptosis in myeloma cells [XREF_BIBR]."
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"In contrast , knockdown of USP5 leads to c-Maf degradation and MM cell apoptosis [ 8] ."
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"In myeloma cells , USP5 stabilizes the c-Maf transcription factor , where inhibition of USP5 promotes c-Maf degradation and leads to apoptosis in myeloma cells [ 15 ] ."
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"Ectopic expression of USP5 significantly increased the transcriptional activity of c-Maf in terms of the measured luciferase activity."
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"Notably, we found that USP5 mRNA expression was also decreased by mebendazole, suggesting that mebendazole might suppress USP5 transcription.Because c-Maf turnover is processed via the proteasome, we sought to determine whether mebendazole induced c-Maf Fig. 2 Mebendazole inhibits USP5 expression and induces c-Maf degradation via the ubiquitin-proteasome pathway."
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