IndraLab

Statements

Arsenous acid decreases the amount of KCNH2. 5 / 11
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"Both arsenic trioxide (ATO) and angiotensin II (Ang II) were able to significantly reduce HERG protein expression, while also increasing PML SUMOylation and accelerating the formation of PML-NBs."
28525371
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"Ficker et al. (2004) demonstrated that arsenic trioxide did not show any direct inhibitory effect on hERG channel activity, whereas long-term exposure of hERG-expressing cell lines and ventricular myo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24998878
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"cardiac glycosides, arsenic trioxide, pentamidine, and ketoconazole) ( Ficker et al., 2004; Kuryshev et al., 2005; Takemasa et al., 2008; Wang et al., 2007 ) reduced hERG membrane expression by inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27575519
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"cardiac glycosides, arsenic trioxide, pentamidine, probucol and ketoconazole) ( Wang et al., 2007; Ficker et al., 2004; Kuryshev et al., 2005; Guo et al., 2007; Takemasa et al., 2008 ) reduce hERG sur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20951697
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"Unlike other drugs that prolong the QT interval by blocking the cardiac I Kr channel, arsenic trioxide is claimed to block the expression of the I Kr protein (hERG) in cardiac cells."
23507039