IndraLab

Statements

USP15 decreases the amount of IFNB1. 3 / 6
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"In contrast to miR-26a, overexpression of USP15 suppressed the expression of IFN-β (Fig. 4A) and the representative ISGs (Fig. 4B), thus promoting HEV replication (Fig. 4C)."
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"Through real-time RT-PCR, we also found that USP15-WT, USP15-C269A and USP15-H862A inhibit the transcription of endogenous IFNB1 gene and the SEV induced expression of ISGs."
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"Correspondingly, USP15 knockdown stimulated the expression of IFN-β and ISGs in the presence of SeV (Fig. 7F, lane 1 and lane 3) or HEV (Fig. 7G, lane 1 and lane 3), whereas miR-26a failed to achieve further stimulation once USP15 was downregulated (Fig. 7F and G, lane 3 and lane 4)."
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