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OTUB1 binds RNF168. 2 / 3
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"Instead, OTUB1 binds and inhibits the RNF168 associated E2s (UBC13 and UBE2N and E2s of the UBE2D and UBE2E families) through assembly of a pseudocleavage product in its catalytic site (Juang et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB1 binds to UBC13 (UBE2N), an E2 ubiquitin-conjugating enzyme for RNF168, and restricts its interaction with RNF168, suppressing the DSB responses by inhibiting RNF168-induced polyubiquitylation independently of its catalytic activity [64]."
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