IndraLab

Statements

Bevirimat inhibits CASP1. 22 / 22
| 22
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"A recently developed HIV-1 inhibitor, PA-457 or bevirimat, targets the CA-SP1 cleavage site to prevent virion maturation."
18657842
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"BVM specifically inhibits CA-SP1 cleavage, which occurs late in the Gag proteolytic cleavage cascade [XREF_BIBR, XREF_BIBR]."
22888428
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"This observation suggests that Bevirimat not only prevents CA-SP1 cleavage but also may stabilize the immature lattice 33."
21762804
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"Although bevirimat specifically disrupts CA-SP1 cleavage, it has been shown that the compound does not affect the viral PR function XREF_BIBR, XREF_BIBR."
26713265
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"Bevirimat causes a dose dependent inhibition of CA-SP1 cleavage and severely impairs HIV infectivity in human thymocytes."
21602280
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"BVM does not inhibit CA-SP1 processing in the context of monomeric Gag in solution [XREF_BIBR], but instead requires Gag assembly for its activity [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
22888428
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"The observation that bevirimat delays but does not completely block CA-SP1 processing suggests that the presence of uncleaved CA-SP1 may disrupt the maturation process in trans."
20172577
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"The precise mechanism by which bevirimat prevents cleavage of CA-SP1 has not been fully elucidated; however, a large body of experimental data appears to suggest that the CA-SP1 junction of an oligomeric form of Gag within the immature particles is molecular target of bevirimat XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
26713265
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"Two working models have been proposed to explain how bevirimat blocks processing of CA-SP1 cleavage site."
26713265
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"We found that the BVM analogs could effectively block CA-SP1 processing of HIV-1 clade C in contrast to the parental BVM, which was completely inactive against the clade C clones."
27264714
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"First, bevirimat does not inhibit CA-SP1 processing in the context of monomeric Gag in solution but instead requires immature virus assembly for its activity."
19534569
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"XREF_BIBR - XREF_BIBR Bevirimat (XREF_FIG) inhibits HIV-1 maturation by preventing the cleavage of CA-SP1 (p25) Gag into Capsid (p24) and SP1 (p2)."
21084190
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"A recently developed HIV-1 inhibitor, PA-457 or bevirimat, targets the CA-SP1 cleavage site to prevent virion maturation."
18657842
reach
"It is noteworthy that BVM disrupts but does not completely block CA-SP1 processing; some mature CA is generated even at high concentrations of the compound."
23144615
reach
"Although the mechanism by which PA-457 prevents cleavage of CA-SP1 has not been fully defined, recent data suggest that the compound binds directly the CA-SP1 region of an oligomeric form of Gag withi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17586320
reach
"Furthermore, in our in vitro maturation system, the maturation inhibitor BVM not only blocked cleavage of CA-SP1 but also partially protected the MA-CA cleavage site."
27958264
reach
"To determine whether BVM disrupts CA-SP1 processing in the context of the L363I and M367I mutations, we evaluated the effect of this compound on levels of CA, CA *, and CA-SP1 in virions by quantitative radioimmunoprecipitation analysis."
20172577
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"Furthermore, bevirimat was shown to block CA-SP1 processing in vitro when Gag self assembled into VLPs but not in the absence of assembly [91]."
18468560
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"The precise mechanism by which BVM inhibits CA-SP1 cleavage has not been established."
19782103
reach
"Further, BVM binds to a pocket formed during Gag oligomerization, as BVM does not inhibit CA-SP1 processing in the context of monomeric Gag in solution, but rather requires Gag assembly for its activity."
19782103
reach
"Since bevirimat treatment of virus producing cells does not completely block CA-SP1 processing XREF_BIBR, the degree of cleavage in the resulting particle preparations was determined by immunoblot (XREF_FIG)."
24915417
reach
"Previous studies demonstrated that BVM does not completely block CA-SP1 processing but acts as a kinetic inhibitor to delay PR mediated cleavage at this site."
20172577