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USP4 inhibits RIPK1. 5 / 5
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"USP4 might negatively regulates RIP1-mediated NF-κB activation and promotes TNF-α-induced apoptosis in FaDu cells, as well as directly interacted with receptor-interacting protein 1 (RIP1) and deubiquitinated K63-linked ubiquitination from RIP142."
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"In this study, we demonstrated that USP4 negatively regulated RIP1-mediated NF-κB activation and promoted TNF-α-induced apoptosis through interacting with RIP1 and deubiquitinating K63-linked ubiquiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we found USP4 negatively regulated RIP1-induced NF-κB activation ( Fig. 3 B)."
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"But, cotransfection of USP4 greatly decreased the polyubiqutination of RIP1 in the setting of ubiquitin WT or K63 transfected cells ( Fig. 4 B), but not in the K48-transfected cells ( Fig. 4 B), indic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we demonstrate that de-ubiquitinating protease USP4 negatively regulates RIP1-mediated NF-κB activation and promotes TNF-α-induced apoptosis through interacting with RIP1 and deubiquiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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