IndraLab

Statements

AIMP2 activates USP29. 4 / 4
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"Knockdown of parkin increased the level of AIMP2, leading to ultimately USP29 and MYBBP1A accumulation in SH-SY5Y cells."
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"In addition, a recent study revealed that AIMP2–FBP1 complex transcriptionally activates USP29 in oxidative conditions [ xref ]."
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"These results suggest that AIMP2 upregulates USP29 and MYBBP1A in the absence of parkin activity, contributing to PD pathogenesis."
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"USP29 is induced by JTV1 and FBP driven transcription in response to oxidative stress, and was also shown to be important for the full activation of PUMA and apoptosis [XREF_BIBR]."
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