IndraLab

Statements

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits IRF3. 4 / 4
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"Inhibition of IRF3 activation by BX795 in HepG2 and C3A cells prevented synthesis of interferon stimulated genes and improved HEV replication in these cells."
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"Because BX795 completely prevents Alpinone-dependent upregulation of IFNa and IRF3, the flavonoid targets seem to be upstream of the kinases TBK1 and IKKε."
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"First, we pretreated MDMs with BX795, which potently blocks IRF3 activation and interferon production through inhibition of the IKK related kinases TANK binding kinase 1 and IKKepsilon."
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"BX795, an inhibitor of TBK1 and IKKepsilon, inhibited the activation of IRF3 (XREF_FIG, 4 th lane), and restored the inhibition of TGF-beta-induced transcription by TpIC (XREF_FIG, lanes 3, 4)."
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