IndraLab

"In addition, LIMP-2 can bind to TSP1 and TSP2 (not depicted)."

"In certain circumstances, TSP-1 can bind to LIMPII and promote cell adhesion (27)."

"To test whether LIMPII also binds TSP1, a LIMPII peptide corresponding to the TSP1 binding domain of CD36 was expressed as a recombinant glutathione S-transferase (GST) fusion protein."

"Because LIMP-2 is predominantly localized on intracellular membrane-bound compartments and exhibits only low levels of cell-surface expression (), it is possible that the interaction between LIMP-2 an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"We recently showed that the corresponding sequence of the CD36 homolog LIMPII bound TSP1 with high affinity, confirming a functionally identical domain."

"Similarly, while we showed that Thbs1 induces Smad2/3 and ATF4 signaling directly in skeletal muscle, which itself could underlie induction of some autophagic genes, Thbs1 also directly binds to LIMPII (SCARB2) that is involved in lysosome formation and processing from the ER compartment where Thbs1 is also present."

"To determine the extent of TSP1 contribution to saliva inhibition of HIV infectivity, clarified saliva samples were passed over affinity columns of immobilized TSP binding LIMPII fusion protein LFP75-155 before virus preincubation."

"To test whether LIMPII also binds TSP1, a LIMPII peptide corresponding to the TSP1 binding domain of CD36 was expressed as a recombinant glutathione S-transferase (GST) fusion protein."

"Both hyperactivity and impairment of the ALP results in skeletal muscle atrophy. xref – xref Furthermore, suppression of autophagy by muscle-specific deletion of Atg7 induces a compensatory upregulation of the proteasome system. xref Similarly, while we showed that Thbs1 induces Smad2/3 and ATF4 signaling directly in skeletal muscle, which itself could underlie induction of some autophagic genes, xref – xref Thbs1 also directly binds to LIMPII (SCARB2) that is involved in lysosome formation and processing from the ER compartment where Thbs1 is also present. xref Thus, future studies will investigate whether Thbs1 directly or indirectly interacts with the ALP and UPS and whether this interaction occurs at the transcriptional, translational, and/or post-translational level."

"To further determine the THBS1 signalling pathways involved in proliferation and apoptosis regulation in MDCK cells and whether there was any interaction between THBS1 and SCARB2 , we performed differential expression assays of the downstream target genes of the PI3K/Akt , P53 , and TGF-/Smad signalling pathways, as well as the predicted interacting gene SCARB2 , with the THBS1-knockdown and -overexpression groups of cells."

"Therefore, we speculated that there was no interaction between the THBS1 and SCARB2 proteins."

"Because LIMP-2 is predominantly localized on intracellular membrane bound compartments and exhibits only low levels of cell-surface expression (Okazaki et al., 1992; Suarez-Quian, 1987), it is possibl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"60 TSP1 binds to the CD36, LIMP-2, Emp sequence homology domain (AA 93-155) via its TSR, and oxLDL binds to the site (AA 155-183) next to the CD36, LIMP-2, Emp sequence homology domain."

"As well as the CD36 protein, LIMPII binding to adhesive glycoprotein TSP-1 may affect platelet adhesion, angiogenesis, and apoptotic cells internalization."