IndraLab

Statements


USP9X deubiquitinates AMOT. 3 / 3
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"Thus, it appears that the direct effect of limiting deubiquitylation of AMOT by USP9x offsets the reduced potential for ubiquitylation due to lower E3 ligase levels."

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"USP9X in the DUBs (ubiquitin-specific protease family) could bind to and deubiquitinate AMOT."

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"USP9X also ameliorates the oncogenic activity of transcriptional coactivator YAP and tafazzin, which are core components of the Hippo pathway, by deubiquitinating their inhibitor, angiomotin (10)."