IndraLab

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USP15 bound to PARP1 activates cell population proliferation. 2 / 2
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"For example, the deubiquitinase USP15 interacts with and deubiquitinates PARP1, promoting its stability and thereby stimulating DNA repair, genomic stability, and the proliferation of triple‐negative breast cancer cells."

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"Here, we demonstrated that the deubiquitinase USP15 interacts with and deubiquitinates PARP1 to promote its stability, thereby stimulating DNA repair, genomic stability and TNBC cell proliferation."