IndraLab
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"However, signalling by LPA receptors may also lead to inhibition of K2P channels as TREK-1 currents were inhibited by LPA when recombinantly expressed in Xenopus oocytes20.According to the above mentioned channels their level of expression and their mode of regulation determine the excitability of a neuron."
reach
"Although the dependence of the pain response upon inhibition of TREK-1 by LPA has not been demonstrated yet, it can be hypothesized if the channel is inhibited by LPA, a possible physiological consequence on the pain pathway would be a decrease in the threshold to pain and, under this scenario, LPA would function as an algogenic molecule through modulation of TREK-1 activity under pathological situations where LPA's extracellular levels are increased."