IndraLab

Statements

USP6 activates Interferon. 5 / 5
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"We previously reported that USP6 is sufficient to induce type I and type II IFN response gene signatures, which includes the immunostimulatory chemokines CXCL9 and CXCL10 (20)."
37615015
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"Not only does USP6 independently induce activation of the IFN signaling mediators JAK1 and STAT1, but it also renders ES cells exquisitely responsive to exogenous IFNs, potentiating activation of STAT1 and STAT3."
30131449
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"Single gene complementation of two Cluster V mutants, Tn : : Rv0712 and Tn : : hrp1 (hypoxic response protein 1, Rv2626c), restored the type I IFN response (XREF_FIG), suggesting that each of these genes is required for induction of type I IFNs."
28505176
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"USP6 also triggered surface stabilization of the type I and type II IFN receptors, IFNAR1 and IFNGR1, rendering Ewing sarcoma cells hyperresponsive to ectopic IFNs with resultant synergistic induction of IFN response genes, including CXCL10 (20)."
37615015
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"Henrich and Coll showed that USP6 modulates the IFN (interferon) response in ES cells by potentiating the activation of STAT1 and STAT3 [184] ."
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