IndraLab

Statements


USP13 increases the amount of MYC. 5 / 5
| 5

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"In vitro analysis showed inducible disruption of USP13 in GSCs by 70% reduced c-Myc protein levels and inhibited GSC proliferation (XREF_FIG)."

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"Targeting USP13 reduces c-Myc protein levels and impairs GSC maintenance."

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"As USP13 functions as a deubiquitinase that also interacts with c-Myc (XREF_FIG) and the preferential expression of USP13 in GSCs positively regulates c-Myc protein levels (XREF_FIG), we hypothesized that USP13 might mediate deubiquitination of c-Myc protein to prevent its degradation and stabilize c-Myc in GSCs."

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"In this study, we demonstrated that USP13 mediated deubiquitination and FBXL14 mediated ubiquitination regulate c-Myc protein levels in glioma cells and play a critical role in controlling the maintenance or differentiation of GSCs (XREF_FIG)."

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"The ubiquitination assay demonstrated that disruption of USP13 by shRNA markedly increased c-Myc ubiquitination and reduced c-Myc protein level in GSCs (XREF_FIG)."