IndraLab

Statements

USP22 activates HK2. 6 / 6
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"In addition of USP22, USP29 also deubiquitinates HIF1α, contributing to sorafenib resistance in HCC cells by promoting the transcriptional activation of target genes, especially hexokinase 2 (HK2), a key enzyme in glycolytic pathway [168]."
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"In addition of USP22, USP29 also deubiquitinates HIF1α, contributing to sorafenib resistance in HCC cells by promoting the transcriptional activation of target genes, especially hexokinase 2 (HK2), a key enzyme in glycolytic pathway [168]."
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"Overexpression of USP22 in HCC cell lines, under hypoxic conditions, significantly enhanced glycolysis, as it upregulated the mRNA expression of key glycolytic enzymes (HK2, PDK1, and ENO1)."
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"Therefore, to investigate the molecular mechanism by which USP22 activates HK2 in osteosarcoma cells, we verified whether endogenous USP22 and HK2 directly bind to 143B cells."
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"Therefore, to investigate the molecular mechanism by which USP22 activates HK2 in osteosarcoma cells, we verified whether endogenous USP22 and HK2 directly bind to 143B cells."
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"USP22 Promotes Osteosarcoma Progression by Stabilising β-Catenin and Upregulating HK2 and Glycolysis."
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