IndraLab

Statements

Dioxygen inhibits NFKB1. 4 / 4
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"Decreased p50 suggested the presence of a high oxygen affinity hemoglobin (Hb) variant."
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"Conversely, a leftward shift of the oxygen dissociation curve (a decrease in p50), results in increased hemoglobin- oxygen affinity and hence decreased oxygen delivery to the peripheral tissues."
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"The normalization of the levels of mitochondrial oxygen radicals by these agents inhibits glucose-induced activation and activation of Protein Kinase C, accumulation of sorbitol, and activation of NFkB."
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"Secondly, NF-KB activation can be inhibited by many antioxidants, metal chelators or oxygen scavengers (for a review, see [21])."
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