IndraLab

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(-)-epigallocatechin 3-gallate inhibits MYD88. 4 / 4
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"In addition, EGCG can finally induce the degradation of TLR-4 co-factor MyD88 adaptor-like (MAL) protein, which links TLR-4 signaling to NF-κB activation, by enhancing the activation of the suppressor of cytokine signaling 1 (SOCS1), which dampens inflammatory responses as a kind of compensatory anti-inflammatory pathway [14] (Figure 5)."
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"3) EGCG (20mg/Kg, i.p.), 1, 24 and 48h after paraquat administration in mice, attenuates ALI, the activation of NF-kappaB and upregulation of toll like receptor 2, 4 and 9, as well as their adaptors MyD88 and TRAF6 in the lung."
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"A study also has shown that EGCG inhibits MyD88 dependent signaling pathways and TIR domain containing adaptor inducing IFN-beta (TRIF)-dependent signaling pathways of TLRs in RAW264.7 cells [XREF_BIBR]."
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"EGCG inhibited the activation of NF-kappaB and the upregulation of TLR 2, 4 and 9 as well as their adaptors MyD88 and TRAF6 in the lungs following PQ challenge."
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