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JOSD1 leads to the deubiquitination of mutated JAK2. 1 / 1

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"JOSD1 deubiquitinates and stabilises mutant JAK2 (JAK2-V617F), and therefore, inactivation of JOSD1 via small molecules led to the degradation of mutant JAK2 in MPNs providing a novel therapeutic approach for the disease [23]."

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IndraLab

Statements

JOSD1 leads to the deubiquitination of mutated JAK2. 1 / 1

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