IndraLab

Statements

USP18 binds JAK1. 4 / 4
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reach
"Interestingly, USP18 specifically binds to the second chain of the type I IFN receptor subunit IFN α/β receptor 2 (IFNAR2) and competes with Janus kinase 1 (JAK1) for binding to IFNAR2, which impairs the association of JAK with the IFN receptor and attenuates IFN signaling ."
36319753
reach
"Based on mutational studies it was suggested that USP18 binds to the intracellular region of type I IFN receptor subunit IFNAR2 and outcompetes the downstream kinase JAK1 thereby abrogating IFN signaling XREF_BIBR."
28165509
sparser
"Binding of UBP43 to IFNAR2 in vivo displaced JAK1 from IFNAR2 and led to the inhibition of the downstream phosphorylation cascade and other signaling events xref ."
25578520
sparser
"The molecular mechanisms remain incompletely understood, but ISG15 seems to stabilize binding of USP18 to JAK1 which inhibits activation of STATs."
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