IndraLab

Statements

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile inhibits NLRP3. 3 / 3
| 3
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"Taken together, the TXNIP antagonist verapamil could inhibit activation of the NLRP3 inflammasome, inflammatory responses and oxidative stress to alleviate LPS and GalN induced ALF."
34031983
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"Furthermore, verapamil or TXNIP siRNA inhibited C2-Cer-mediated upregulation of TXNIP and activation of the NLRP3 inflammasome, suggesting that Cer induces TXNIP overexpression and subsequent NLRP3 inflammasome activation."
| PMC
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"Verapamil inhibits activation of NLRP3 inflammasome and hepatic metaflammation in HF diet fed mice."
30429827