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USP13 inhibits nilotinib. 4 / 4
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"Moreover, overexpression of USP13 inhibits the effect of the tyrosine kinase inhibitor, Nilotinib, and USP13 knockdown enhances the effect of Nilotinib on α-synuclein clearance [ 49 ]."
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"Conclusively, the above findings confirmed that USP13 interacted with and stabilized Bcl‐XL under both physiological and pathological conditions, thus involving in nilotinib‐induced nephrotoxicity.2.5 CQ Relieves Nilotinib-Induced Nephrotoxicity In Vitro."
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"Overexpression of USP13 inhibits the effects of small molecules, including the tyrosine kinase inhibitor, Nilotinib; conversely, USP13 knockdown enhances the effects of Nilotinib on α-synuclein cleara[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, it was shown that overexpression of USP13 could antagonize the positive effects of the drug Nilotinib, which is known to increase α-synuclein clearance in this animal model, whereas USP13 KD augmented the effects of the drug [64]."
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