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Genistein inhibits STAT1. 13 / 14
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"In addition to these four polyphenols, genistein, kaempferol and daidzein have been reported to inhibit the activation of STAT-1 and NF-κB pathways [ 162 ]."
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"Treatment of either AG490 or genistein inhibited IFN-γ-induced STAT-1 transcriptional activity ( Fig. 4 A )."
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"Furthermore, some studies have shown that genistein, as a phytoestrogen, suppressed activations of signal transducer and activator of transcription 1 (STAT1) and NF‐κB p65 pathway (Hämäläinen et al., 2007; Kim & Kim, 2011)."
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"Flavonoids like genistein, kaempferol, quercetin, and daidzein inhibited STAT-1 and NF-kappa B activations in anti-inflammatory effects [XREF_BIBR]."
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"In Murine J774 macrophages, Genistein inhibits the activation of STAT1, another important transcription factor of inducible nitric oxide synthase (iNOS), In the macrophages of Murine J774 macrophages, Genistein inhibits the activation of STAT1, another important transcription factor of inducible nitric oxide synthase (iNOS), explaining the pharmacological effect of Genistein as an anti-inflammatory compound (Hämäläinen et al., 2007)."
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"In addition, genistein, kaempferol, quercetin, and daidzein also inhibited STAT-1 activation."
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"[24] Hamalainen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids : genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages."
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"These observation was consistent with the anti-inflammatory effects of some flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF- κ B activation, whereas flavone, isorhamne[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Daidzein, genistein, kaempferol, and quercetin also inhibited the STAT-1 pathway [54]."
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"Anti-Inflammatory Effects of Flavonoids : Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-kappaB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-kappaB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages."
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"The mechanisms by which genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 activation are not known, but may be associated with inhibition of phosphorylation of STAT-1 or its up-stream kinase JAK2 [XREF_BIBR]."
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"Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS."
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"Daidzein and genistein also inhibited activations of STAT-1 and NF-kappaB, which are important transcription factors for iNOS [XREF_BIBR, XREF_BIBR]."
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