IndraLab

Statements

USP2 increases the amount of TP53. 3 / 3
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"Indeed, inactivation of USP2 increases the levels of both p53 and PD-L1 in tumors, suggesting that the tumor suppression activity of USP2 inhibition may be potentiated by the PD-1/PD-L1 immune checkpoint blockade."
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"Notably, USP2 overexpression promoted p53 expression in the nucleus, while suppressing p53 expression in the cytoplasm (Fig. 4D)."
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"Ubiquitination assays evaluated the ubiquitination levels of p53 following USP2 overexpression."
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