IndraLab

Statements

E6 activates CYLD. 9 / 9
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"For example, the E6 protein of human papillomavirus (HPV) targets CYLD for ubiquitination and proteasomal degradation, leading to persistent NF-kappaB activation by hypoxia in HPV infected cancer cells 130."
21135871
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"Interestingly, there is a precedent for E6 influencing signaling pathways involving K63 branching : HPV E6 targets the lysine 63 specific Deubiquitinase CYLD (a negative regulator of the NF-kB pathway), thereby causing prolongation of hypoxia induced NF-kB activation."
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"Therefore, E6 targeting of CYLD appears to be an essential step in HPV mediated tumorigenesis."
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"One study demonstrated that Cyld is targeted for degradation by HPV (human papillomavirus) E6 virus, to prolong NF-kappaB activation following hypoxia [XREF_BIBR]."
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"Based on these results, we concluded that E6 targets CYLD for proteasome mediated degradation."
18977328
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"Under hypoxic conditions, the HPV encoded E6 protein inactivates the CYLD tumor suppressor, a negative regulator of the NF-kappaB pathway and thereby allows for unrestricted activation of NF-kappaB."
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"Under hypoxic conditions, high-risk E6 also inactivates the CYLD tumor suppressor through interactions with CYLD deubiquitinase to allow unrestricted activation of NF-kappaB XREF_BIBR."
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"9 In cancers related to human papillomavirus (HPV), such as cervical cancer, CYLD is targeted by HPV E6 protein for degradation."
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"For these studies, we studied the state of CYLD ubiquitination in SiHa and HeLa cells that were treated with E6 specific siRNA or control siRNA."
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