IndraLab

Statements

USP6 binds RNA14. 4 / 4
| 4
reach
"Rna14 can further associate with Pcf11 and Hrp1 and also binds the Pfs2 and Cft1 subunits of CPF."
17151076
reach
"The Hrp1/Rna14 interaction has been mapped to Hrp1 RRMs by NMR (Barnwal et al, 2012), but the structural details remain unknown."
35022249
reach
"These findings support the idea that controlled Mex67 recruitment by Hrp1 determines nuclear export and that only Rna14-bound Hrp1 can interact with the export receptor.If this model would be true, one would expect that Hrp1 is still bound to cleavage-defective mRNAs."
37351636
reach
"Interestingly, and in contrast to Hrp1, when we performed a similar RIP experiment with Rna14, we found an over ∼50% decrease in its association with the target mRNAs (Figure 5G, H), supporting a model in which Rna14 binding to Hrp1 might be the trigger of the Mex67 recruitment and suggesting Rna14 to function as an indicator of correct cleavage."
37351636