IndraLab

Statements

USP2 activates SKP2. 3 / 3
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"ML364, a small-molecule inhibitor of USP2, accelerates SKP2 degradation."
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"Surprisingly, ectopic USP2 expression caused the dose-dependent accumulation of both SKP2 and SKP2 substrates, p21 (11, 12) and p27 (13, 14, 15) in H1299 and H2170 cells (Fig. 4A)."
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"Interestingly and unexpectedly, USP2-induced SKP2 stabilization did not cause degradation of SKP2 substrates, rather USP2 disrupts SKP2 binding with its substrates via occupying the same LRR domain of SKP2 substrate binding."
34425107