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TNFAIP3 activates cell growth. 3 / 3
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"Moreover, TNFAIP3 induces cell growth arrest and apoptosis, accompanied by down-regulation of nuclear factor-kappa B (NF-kB) activation [XREF_BIBR, XREF_BIBR]."
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"These investigators also evaluated TLR2 on human GC cell lines using DNA microarray-based expression profiling and showed that the TLR2-induced response to human gastric cancer cell growth was upregulated by six anti-apoptotic genes (BCL2A1, BCL2, BIRC3, CFLAR, IER3, TNFAIP3) and the downregulation of two tumor suppressor genes (PDCD4, TP53INP1) [20]."
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"These results suggest that the downstream molecular mechanisms responsible for mediating FGFR1 function are through coordinating multiple signaling pathways that govern cell proliferation, behavior and differentiation.Among the iFGFR1-upregulated genes, we further studied the role of TNFAIP3 in FGFR1 signaling-promoted DCIS.COM cell growth."
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