IndraLab

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"These results suggest that the downstream molecular mechanisms responsible for mediating FGFR1 function are through coordinating multiple signaling pathways that govern cell proliferation, behavior and differentiation.Among the iFGFR1-upregulated genes, we further studied the role of TNFAIP3 in FGFR1 signaling-promoted DCIS.COM cell growth."

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"Moreover, TNFAIP3 induces cell growth arrest and apoptosis, accompanied by down-regulation of nuclear factor-kappa B (NF-kB) activation [XREF_BIBR, XREF_BIBR]."