IndraLab

Statements

USP22 decreases the amount of ISG. 3 / 3
| 3
reach
"USP22 controls basal and 2′3′-cGAMP-induced STING ubiquitination, phosphorylation, and activation, and combined loss of USP22 and STING rescues ISG expression, STAT signaling, and IFN-λ production."
35933402
reach
"loss of USP22 and STING rescues ISG expression, STAT signaling and 142 IFN-λ production."
| DOI
reach
"At present, the functional role of 3CLpro-mediated inactivation of RNF20 for H2Bub1 still remains to be addressed.Since loss of USP22 mostly affects type III IFN expression and secretion, USP22 likely mediates ISG expression both via epigenetic regulatory mechanisms as well as through long-term IFN-mediated priming effects in hIECs."
35933402