IndraLab

Statements

USP14 inhibits Interferon. 5 / 5
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"USP14 specific inhibitor, IU1, was demonstrated to increase RIG-I-mediated type I IFN production and antiviral responses in vitro and in vivo."
33511009
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"The grouper USP14 has been showed to attenuate interferon antiviral signaling by inhibiting TBK1 and MDA5 [ 24 , 25 ]."
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"USP14 knockdown significantly enhanced RIG-I-triggered type I IFN signaling and inhibited VSV replication both in mouse peritoneal macrophages and THP1 cells."
30466171
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"USP14 inhibited RNA virus induced type I IFN signaling pathway by promoting K63-linked RIG-I deubiquitination."
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"Besides, USP14 specific inhibitor-IU1 increased RIG-I-mediated type I IFN production and antiviral responses in vitro and in vivo."
30466171