IndraLab

Statements

USP10 inhibits MTOR. 4 / 4
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"These results suggesting that loss of USP10 can lead to activation of mTOR signaling in vivo."
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"Moreover , numerous studies have demonstrated that USP10 inhibited mTOR activation and promoted oncogene-induced senescence to exert a tumor-suppressive effect ( 50 , 51 ) ."
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"Specifically, USP10 activates PTEN by preventing its K63 linked polyubiquitination mediated by TRIM25 and suppresses the AKT and mTOR signaling pathway thereby inhibiting NSCLC proliferation, indicating that it may be a potential drug target for cancer treatment."
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"These results indicate that USP10 may inhibit mTOR activation through regulating PTEN/AKT/PI3K and AMPK signaling pathways in HCC cells.To further dissect how USP10 inhibits mTOR activity, we investig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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