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USP10 inhibits MTOR. 14 / 14
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"Thus, we will collect more human lung tissues in future studies to explore USP10 expression and the clinical effects of USP10 on IPF.Taken together, our results suggest that overexpression of USP10 might attenuate pulmonary fibrogenesis by partially promoting autophagy via the Sirt6-mediated AKT/mTOR pathway."
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"In addition, USP10 inhibited the activation of AKT/mTOR signaling (Lu et al. 2018)."
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"These results suggesting that loss of USP10 can lead to activation of mTOR signaling in vivo."
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"To our attention, USP10 was also found to suppress the AKT/mTOR signaling pathway by inhibiting PTEN, but the underlying mechanisms are controversial."
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"Another study showed that USP10 inhibits the AKT/mTOR signaling but does not provide sufficient data on PTEN stability in hepatocellular carcinoma cells (33)."
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"16 Our previous studies have shown that USP10 inhibits mTOR activation and suppresses the proliferation of HCC."
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"These results indicate that USP10 may inhibit mTOR activation through regulating PTEN/AKT/PI3K and AMPK signaling pathways in HCC cells.To further dissect how USP10 inhibits mTOR activity, we investig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In agreement with this finding, depletion of USP10 by sgRNA triggered the activation of AKT/mTOR signaling (Fig. 5E)."
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"Furthermore, USP10 overexpression inhibited the activation of Sirt6-mediated AKT/mTOR pathway in both lung tissues and fibroblasts."
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"Moreover , numerous studies have demonstrated that USP10 inhibited mTOR activation and promoted oncogene-induced senescence to exert a tumor-suppressive effect ( 50 , 51 ) ."
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"USP10 is lowly expressed in NSCLC cells and suppresses the activation of the AKT/mTOR signaling pathway."
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"Mechanistic studies demonstrated that USP10 suppresses the activation of the AKT/mTOR pathway via decreasing the K63-linked polyubiquitination of PTEN, which resulted in the inhibition of the cell viability, proliferation, and migration of the A549 and H1299 NSCLC cell lines."
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"These data thus demonstrated that USP10 might activate PTEN, thus inhibiting the AKT/mTOR signaling pathway."
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"The activation of the AKT/mTOR pathway was confirmed in TGF-β1-induced HLF, and USP10 overexpression inhibited AKT/mTOR activation (Fig. S1F, G)."
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