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USP18 activates Neoplasms. 15 / 16
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"Myeloid-lineage-specific deletion of USP18 suppresses tumor progression."
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"Furthermore, we transfected USP18 overexpression plasmids into bladder cancer cell lines stably overexpressing BCCE4[A] and found that USP18 overexpression restored the tumor‐suppressing function of BCCE4[A] (Figure S26, Supporting Information)."
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"PLX3397 abrogated USP18 deficiency-induced reduction in pro-tumor/immunosuppressive macrophages (Figure 4C), supporting that USP18-mediated downregulation of CSF1R expression contributes to macrophage polarization.In addition to the changes in TAM population, there were significant changes in T cell population."
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"USP18 enhanced tumor growth in vivo via mediating POU4F1 and PRKAA2."
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"41 , 42 Consistent with the above findings, we also found that USP18 could restore the tumor‐suppressing function of BCCE4[A], indicating that USP18 plays an oncogenic role in bladder cancer."
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"Here, we show that deletion of USP18 in myeloid cells suppresses tumor progression."
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"In the tumor, this signaling drives expression of angiogenic and immunosuppressive myeloid chemokines CXCL1, CXCL10, and CCL5; protumor interferon-stimulated genes ISG15 and IFIT3; and oncoprotein USP18, all of which promote tumor growth and metastases, and are selectively blocked by nciLT but not by ciLT."
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"USP18 could promote tumor metastasis in esophageal squamous cell carcinomas via deubiquitinating ZEB1 [13]."
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"It has been reported that USP18, an important protein involved in chemotherapy resistance, can induce autophagy, and inhibition of USP18 can effectively inhibit tumor resistance to the chemotherapy dr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we report that deletion of USP18 in myeloid cells suppresses tumor growth and enhances activation of cytotoxic CD8 cells."
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"USP18 expression in B16 melanoma tumor cells modulates immune cell phenotypes, including increasing MHC class-I expression, impairing tumor cell-mediated inhibition of T cell proliferation and activat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In malignant tumors, USP18 is elevated and activates AKT/mTOR signaling, promotes phosphorylated AKT (p-AKT) and p-mTOR protein expression, leading to cancer cell proliferation and migration (106)."
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"Silencing USP18 reduced tumor growth in vivo by mediating POU4F1/PRKAA2 axis."
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"In males, androgens modulate the expression of USP18 via binding and activation of the androgen receptor (AR) transcription factor, thereby promoting tumor initiation and progression [14]."
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"Compared with normal saline treatment, paclitaxol treatment significantly inhibited tumor growth, and USP18 knockdown slightly reduced tumor growth ( Fig. 4 A&B)."
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