IndraLab

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Hesperetin inhibits KCNH2. 3 / 3
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"Hesperetin blocked hERG potassium channels in a concentration dependent manner."
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"In Xenopus oocyte and in HEK293 cell line it was reported that relatively high concentrations (IC  = 288.8 µM and 23.1 µM) of hesperetin inhibited hERG channel and Kv 1.5 channel which are the pore-forming channel subunits of the rapid (I ) and ultrarapid (I ) delayed rectifier potassium currents, respectively."
38538818
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"Naringenin and hesperetin induced hERG current inhibition was suggested as a possible explanation for the reported QT prolongation in humans following grapefruit juice ingestion ."
38538818