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SIRT1 activates COPS5. 1 / 1
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reach
"The involvement of the deacetylase activity of Sirt1 was confirmed by the ability of its pharmacological inhibitors, nicotinamide (50 mM) and splitomicin (200 microM), to rescue Csn5, Skp2 and beta-TrCP from CG-12-induced changes to their expression levels (XREF_FIG)."