IndraLab

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PSMD14 activates TP53. 5 / 5
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"POH1 Knockdown Attenuates Degradation of p53 and Bim."
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"Knockdown of POH1 dramatically attenuated the degradation of p53 and Bim in QGY-7701 (XREF_FIG A), EC109 (XREF_FIG B), and HCT116 (XREF_FIG C) cells."
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"Although it may seem a bit contradictory, we demonstrate that knockdown of POH1 (a deubiquitining enzyme) could diminish the ubiquitin modification of p53 and Bim, and we speculated there were some reasons."
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"Similarly, overexpression of POH1 increased the levels of p-SMAD3 in p53 , myristoylated AKT- transformed mouse liver progenitor cells (LPC-AKT) [27] (Fig. 3f), as well as the immortalized hepatocytes LO2 (Fig. 3g)."
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"For example, the proteasomal deubiquitinase PSMD14, together with PSMD7 as a heterodimer, promotes p53 protein stability through a non‐canonical pathway independent of the catalytic barrel of the 20S proteasome, function recently implicated in cancer progression (Bustamante et al., 2023)."
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