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COPS5 inhibits ESR1. 1 / 1

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"Mechanistically, amplification and overexpression of COPS5 lead to an ubiquitination and proteasome dependent destabilization of NCoR protein, a corepressor required for tamoxifen mediated suppression of ERalpha target genes, which is considered as a key mechanism of action of the drug."

27375289

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IndraLab

Statements

COPS5 inhibits ESR1. 1 / 1

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