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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 inhibits ESR1. 1 / 1

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"Mechanistically, amplification and overexpression of COPS5 lead to an ubiquitination and proteasome dependent destabilization of NCoR protein, a corepressor required for tamoxifen mediated suppression of ERalpha target genes, which is considered as a key mechanism of action of the drug."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...