IndraLab

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UCHL1 activates Caspase. 4 / 4
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"We found that UCH-L1 is a mediator of caspase independent, non apoptotic cell death also in diseased kidney podocytes by measuring cleavage of the protein PARP-1, caspase activity, cell death and cell morphology."
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"UCH-L1 is a mediator of caspase independent, non apoptotic cell death in diseased kidney podocytes."
24090154
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"Interestingly, Drosophila genetic studies have shown that increased UCH-L1 levels in the eye imaginal discs induces caspase dependent apoptosis, resulting in a rough eye phenotype [XREF_BIBR]."
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"It is possible that this contributes to our observation that UCH-L1 depletion (resulting in reduced Akt phosphorylation) enhanced caspase activation in response to bortezomib."
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