IndraLab

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OTUD7B deubiquitinates FOXM1. 3 / 3
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"In the present study, co-immunoprecipitation (co-IP) assay was used to investigate whether OTUD7B interacts with forkhead box protein M1 (FOXM1) and reduces FOXM1 ubiquitination to stabilize the FOXM1 protein."
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"In the present study, it was revealed that OTUD7B interacts with and deubiquitinates FOXM1 in breast cancer cells, leading to the stabilization of FOXM1."
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"Co-immunoprecipitation assays demonstrated that OTUD7B interacted with forkhead box protein M1 (FOXM1) and reduced the polyubiquitylation of FOXM1 in breast cancer cells; accordingly, FOXM1 protein levels were significantly decreased by OTUD7B knockdown."
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