IndraLab

Statements

USP10 activates apoptotic process. 17 / 18
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"USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway."
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"Furthermore, depletion of USP10 in lung cancer cells causes decreased apoptosis and increased cell survival upon treatment with DNA-damaging agents."
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"USP10 induces activation of TAK1-JNK/p38 signaling pathways to promote hepatocyte inflammation and apoptosis in hepatic I/R injury mouse model [71]."
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"Overexpressing USP10 inhibited invasion, migration, and EMT properties of FTC133-DOX cells and promoted apoptosis."
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"USP10 Heterozygote mice exhibited exacerbated hepatic I/R injury, as evidenced by enhanced liver inflammation via the NF-kappaB signalling pathway and increased hepatocyte apoptosis."
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"Further, USP10’s importance for life is underlined by the fact that USP10 knockout mice died within 1 year due to bone marrow failure with pancytopenia suggesting that USP10 controls differentiation, and apoptosis which are also crucially linked to tumorigenesis."
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"USP10 induced cell apoptosis in FTC133-DOX via regulating ABCG2."
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"It has been reported that knockdown of USP10 in lung cancer cells causes increased cell survival and decreased apoptosis upon treatment with a DNA-methylating and antimetabolite agent (13)."
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"Our results also indicated that overexpression of USP10 promoted apoptosis of DOX resistance thyroid cancer cells."
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"12 Recent research has suggested that USP10 modulates cell proliferation, migration, and apoptosis."
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"In conclusion, these results suggest that USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway."
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"However, after co-transfecting pc-DNA-USP10 cells with pc-DNA-ABCG2, the expression of pro-apoptotic proteins elevated while anti-apoptotic protein was reduced by overexpressing ABCG2 at the same time (Fig. 5B), suggesting that USP10 induced apoptosis in FTC133-DOX cells is mediated by ABCG2."
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"USP10-knockout indicated that USP10, through augmenting formation of SGs, reduced reactive oxygen species (ROS) production and inhibited ROS dependent apoptosis."
| PMC
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"Moreover, USP10 was found to reduce oxidative stress, and abated LPS-induced renal tubular epithelial cell injury and apoptosis."
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"Furthermore, our study demonstrates that lnc-NR3C, acting as a competing endogenous RNA (ceRNA), upregulates USP10 expression by sequestering miR-129-5p, thereby augmenting the stability of the p53 protein and promoting apoptosis."
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"Their results show that the depletion of USP10 in A549 increased cell survival and decreased apoptosis through destabilizing MSH2 [32]."
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"Moreover, overexpression of USP10 promotes the apoptosis of DOX-resistant thyroid cancer cells."
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