IndraLab

Statements

Ziprasidone inhibits KCNH2. 9 / 9
4 1 | 4
tas
No evidence text available
19534531
reach
"Although ziprasidone has been shown to block the HERG channel in vitro and prolong the QTc interval in vivo in man, there have been no reported cases of TdP associated with its clinical use to date."
22033499
reach
"In conclusion, ziprasidone preferentially binds to and blocks open hERG channels."
16325148
ctd
No evidence text available
28551711
reach
"In this study, we examined the biophysical properties and the molecular determinants of the ziprasidone block of wild-type hERG potassium channels stably expressed in HEK-293 cells or wild-type and mutant hERG channels expressed in Xenopus oocytes."
16325148
tas
No evidence text available
21185626
tas
No evidence text available
15911273
reach
"In stably transfected HEK-293 cells, ziprasidone blocked wild-type hERG current in a voltage- and concentration dependent manner (IC (50) = 120nM, 0mV, 37 degrees C)."
16325148
tas
No evidence text available
21055935