IndraLab

Statements

OTUD7B activates HYCC1. 3 / 3
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"Together these findings suggest that the phenotypic changes in HCC cells elicited by OTUD7B rely on the downstream actions of p53."
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"Other phenotypic features consistent with apoptosis observed upon overexpressing OTUD7B in HCC cells were the condensation and fragmentation of nuclear chromatin 49 as detected by flow cytometry and confocal microscopy, respectively (Figure 7F-G), while examination of cleaved caspase 3 staining in HCC xenografts showed that OTUD7B overexpression also increased HCC cell apoptosis rates in vivo (Figure 7H)."
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"This study represents one of several reports showing both negative and positive effects of OTUD7B on tumor cell invasiveness 18, 23, 42, 63, a tumorigenic phenotype which we have not addressed here.We further observed one of the major outcomes associated with the stabilization of p53 via enforced OTUD7B expression involved inducing HCC cell apoptosis, phenocopying the p53 response to cellular insults such as unresolved levels of DNA damage."
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