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KCNMA1 activates cell differentiation. 5 / 5
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"The SLO data also support our earlier hypothesis that monocytes must undergo maturation and differentiation in the circulation before they acquire the ability to roll on inflamed endothelium and that changes in monocyte receptor function are crucial events that enable inflammatory monocytes to traffic to the site of inflammation."
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"Additionally, the expression of USP7, which seems to have a direct interaction with the Wnt/β-catenin pathway (Friese et al., 2019), was increased in the bones and osteoblasts of Osterix-Cre(+); Kcnma1f/f mice.These results demonstrate that Kcnma1 deficiency inhibits osteogenic differentiation of primary osteoblasts via the Wnt/β-catenin pathway and that the deubiquitinating enzyme USP7 seems to participate in osteogenesis."
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"Another study reported that an aged SLO microenvironment underlies multiple defects in homing, priming, and effector differentiation that led to poor CD4 + T cell response and hindered the ability to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previously, knockout of the BK channel using the TALEN technique in osteoblasts resulted in decreased proliferation and inhibited differentiation [55]."
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"Collectively the data suggest that chronic peripheral (non lymphoid tissue) sites of antigen deposition are detrimental to the development and/or maintenance of immune memory while SLO sites of antigen promote protective memory by modulating the differentiation status of the circulating memory pool."
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