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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mutated ATXN3 increases the amount of PMAIP1. 1 / 1

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"Recent studies have also shown that the mutant ATXN3 causes p53 mediated neuronal death in vitro and in vivo by activating the transcription of the p53-inducibe pro apoptotic genes such as BAX (Bcl2 associated X protein) and PMAIP1 (PUMA, p53 upregulated modulator of apoptosis), triggering mitochondrial apoptotic pathways [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...