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Mutated ATXN3 increases the amount of PMAIP1. 1 / 1

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"Recent studies have also shown that the mutant ATXN3 causes p53 mediated neuronal death in vitro and in vivo by activating the transcription of the p53-inducibe pro apoptotic genes such as BAX (Bcl2 associated X protein) and PMAIP1 (PUMA, p53 upregulated modulator of apoptosis), triggering mitochondrial apoptotic pathways [XREF_BIBR, XREF_BIBR]."

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IndraLab

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Mutated ATXN3 increases the amount of PMAIP1. 1 / 1

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