IndraLab

Statements

OTUB2 is sumoylated. 8 / 8
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sparser
"In breast cancer patients, there is a good correlation between the levels of KRAS and the levels of OTUB2 sumoylation as wells as the levels of Yap/Taz protein expression ( xref )."
33869224
sparser
"A yet-unknown SUMO-interacting motif (SIM) in YAP and TAZ was required for the association of YAP/TAZ with SUMOylated OTUB2."
36264492
sparser
"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ."
36264492
sparser
"Sumoylated OTUB2 interacts specifically with yet-unidentified sumo interaction motifs (SIMs) in WW domain-containing transcription factor (TAZ) and Yes-associated protein (YAP) to regulate protein activity and TAZ/YAP polyubiquitination in a Hippo-independent manner."
35110531
sparser
"Additionally, EGF therapy or KRAS mutation stabilizes YAP/TAZ expression and OTUB2 sumoylation [ xref ]."
35110531
sparser
"Poly-SUMOylated OTUB2, which was induced by Epidermal growth factor (EGF) and oncogenic KRAS, was shown to bind and activate YAP/TAZ promoting tumor metastasis [ xref ]."
31619007
sparser
"We also identified a yet-unknown SUMO-interacting motif (SIM) in YAP and TAZ required for their association with SUMOylated OTUB2."
30472188
sparser
"Hence, OTUB2 sumoylation represents a novel mechanism that links the oncogenic EGFR-RAS pathway to Yap/Taz activation and a potential therapeutic target for cancer treatment."
33869224