IndraLab

Statements

PSMD14 activates IRF3. 3 / 3
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"In contrast, the deubiquitinase PSMD14/POH1 prevents autophagic degradation of IRF3 by cleaving the K27-linked poly-ubiquitin chains on IRF3 to maintain IRF3-mediated type I IFN activation (Wu et al., 2021)."
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"The autophagic degradation of IRF3 mediated by PSMD14 or CALCOCO2 ensures the precise control of IRF3 activity and fine-tunes the immune response against viral infection."
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"However, PSMD14 the peak marker of this pathway prevents IRF3 autophagic degradation and therefore permits IRF3-mediated type I IFN activation (53)."
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