IndraLab

Statements

USP12 inhibits cell population proliferation. 5 / 7
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"As a result, depleting Usp12 decreased PC cellular proliferation and increased cellular apoptosis suggesting it may be a potential target for CRPC therapy [XREF_BIBR]."
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"As shown in XREF_FIG B, knockdown of WDR48 and USP12 by shRNA accelerated the rate of cell proliferation compared with control shRNA transfected cells."
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"Functionally, we show that WDR48 and USP12 suppress proliferation of tumor cells."
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"In contrast, overexpression of WDR48 and USP12 (XREF_FIG C) suppressed cell proliferation similarly to PHLPP1 (XREF_FIG D)."
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"We further established that Usp12 depletion reduced PC cell proliferation and induced apoptosis, furthermore Usp12 levels are increased in PC tissue [XREF_BIBR]."
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