IndraLab

Statements


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"However, the mechanism by which STAMBPL1 activates the transcriptional activity of FOXO1 has not been elucidated."

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"This suggests that STAMBPL1 enhances the transcriptional activity of FOXO1 on GRHL3 by interacting with nuclear FOXO1."

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"STAMBPL1 was shown to increase the transcriptional activation of FOXO1 at the GRHL3 promoter (Figure 7K), and it also bound to the GRHL3 promoter which could be disrupted by FOXO1 knockdown (Figure 7L)."