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USP19 deubiquitinates TRAF2. 1 / 1
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"For example, myocardial-specific expression of A20, a DUB, improves left ventricular function and alleviates compensatory myocardial hypertrophy induced by myocardial infarction.7 Another 2 DUBs, USP4 and USP18, attenuate hypertension-induced pathological cardiac hypertrophy by directly binding to TAK1.8 9 In addition, the deubiquitinase OTUD1 regulates the progression of diabetic cardiomyopathy by regulating YB-1 and inhibiting its activation10 and USP19 alleviates doxorubicin-induced cardiomyopathy by deubiquitinating TRAF2 and preventing its degradation."
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