IndraLab

Statements

STAMBP activates cell population proliferation. 7 / 7
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"Using the human cortical organoids (hCOs) model, we showed that the STAMBP deficiency disrupts the proliferation of neural stem cells (NSCs), leading to a dramatic size reduction in hCOs."
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"Performing functional experiments, we further demonstrated that the upregulation of STAMBP promoted the proliferation and invasion of TNBC cells, while the knockdown of STAMBP suppressed the malignant progression of TNBC cells."
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"STAMBP deletion results in smaller cortical organoids and impairs neural stem cell proliferation."
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"Functionally, the knockdown of STAMBP inhibited the proliferation, migration, and invasion of multiple TNBC cell lines."
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"Knockdown of STAMBP could inhibit the proliferation, migration and invasion of multiple TNBC cell lines [28]."
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"Overexpression of STAMBP released RAI14 knockdown-induced inhibition of cell proliferation (Supplementary Fig. 3b), cell migration (Supplementary Fig. 3c) and cell invasion (Supplementary Fig. 3d)."
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"Novel compound heterozygous mutation in STAMBP causes a neurodevelopmental disorder by disrupting cortical proliferation."
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