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ATXN3 activates ITGA5. 1 / 1

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"Our results show that ATXN3 rescues ITGA5 from proteasomal degradation in neurons and that polyQ expansion causes a partial loss of this cellular function, resulting in reduced integrin signalling and neuronal cytoskeleton modifications, which may be contributing to neurodegeneration."

25143392

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IndraLab

Statements

ATXN3 activates ITGA5. 1 / 1

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